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Oxidized Ellagitannins in Medicinal Plants and Their Biological Activities

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Other Title
  • 薬用植物中の酸化型エラジタンニン成分とその生理活性
  • ヤクヨウ ショクブツ チュウ ノ サンカガタ エラジタンニン セイブン ト ソノ セイリ カッセイ
  • 薬用植物中の酸化型エラジタンニン成分とその生理活性

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Geraniin and related dehydroellagitannins having a reactive dehydrohexahydroxydiphenoyl (DHHDP) group in the molecule have been widely found in the euphorbiaceous and geraniaceous plants. Further investigation on the polyphenols in Phyllanthus flexuosus, Acalypha hispida and Geranium thunbergii belonging to each family resulted in the isolation of eleven new analogues of geraniin and the characterization of their complex structures possessing a new highly oxidized acyl unit produced from the DHHDP group. New highly oxidized ellagitannins of other types, i.e., those having a gluconic acid core and C-glucosidic ellagitannin oligomers were also found in Elaeagnaceae and Fagaceae. Diverse biological properties including anti-ulcer and anti-tumor promoting effects, and antibacterial activity against Helicobacter pylori and antifungal activity were also exhibited by those highly oxidized ellagitannins.



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