New Paradigm of Biomolecular Soft-interfaces as Chiral Reaction Fields for Supramolecular Asymmetric Photochirogenesis
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- WADA Takehiko
- Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University
Bibliographic Information
- Other Title
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- 生体高分子表面をキラルソフトインターフェース反応場として活用した超分子不斉光化学系の創製 ―環境調和型不斉合成法の開発を目指して―
- セイタイ コウブンシ ヒョウメン オ キラルソフトインターフェース ハンノウジョウ ト シテ カツヨウ シタ チョウブンシ フセイ ヒカリカガクケイ ノ ソウセイ : カンキョウ チョウワガタ フセイ ゴウセイホウ ノ カイハツ オ メザシテ
- —環境調和型不斉合成法の開発を目指して—
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Abstract
Asymmetric photochemistry provides us with new versatile routes to novel/strained chiral compounds. Recently, much effort has been devoted to the supramolecular photochirogenesis, exploiting the chiral environment of natural and synthetic hosts, such as cyclodextrin, modified zeolite, ds-DNA and protein. Photochirogenesis with biomolecule is particularly attractive and advantageous in view of the inherently chiral, finely-defined 3D structures. Serum albumins are the most abundant and well characterized water-soluble plasma proteins, which transport hydrophobic compounds. However, little is known about the supramolecular photochirogenesis with the protein used as chiral environment for reaction. We employed Bovine and Human Serum Albumin (BSA and HSA) as a chiral supramolecular host and 2-anthracenecarboxylate (AC) as a substrate. The photocyclodimerization of AC was performed in aqueous buffer solutions in the presence of BSA and HSA to give the [4+4] cyclodimers with high enantioselectivities of up to 90% ee.
Journal
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- Hyomen Kagaku
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Hyomen Kagaku 33 (1), 27-33, 2012
The Surface Science Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001206457055744
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- NII Article ID
- 130004486696
- 10030442978
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- NII Book ID
- AN00334149
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- ISSN
- 18814743
- 03885321
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- NDL BIB ID
- 023470536
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed