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  • クレアチンシャトル ノ ダイチョウ ガン ニ オケル ヤクワリ
  • Roles of the creatine shuttle in colorectal cancer

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type:Article

The creatine shuttle is a system that transfers energy generated by oxidative phosphorylation to the cytoplasm by phosphorylating creatine with mitochondrial vreatine kinase (MTCK) and dephosphorylating phosphocreatine with creatine kinase B (CKB) in the cytoplasm. The relevance of this system to cancer has not been clear. The creatine shuttle not only transports ATP generated in the mitochondria to the cytoplasm as phosphocreatine, but also provides ATP that causes phosphorylation in multiple phosphorylation signal systems. By inhibiting these two functions of the creatine shuttle, it is possible to suppress the progression of cancer and the development of cancer stem cells.

identifier:Journal of Nara Medical Association Vol.74 No.4,5,6 p.31-34 (2024.01)

identifier:13450069

identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4406

identifier:Journal of Nara Medical Association, 74(4,5,6): 31-34

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