A quantitative study of the optic nerve in diabetic mutant, Otsuka Long-Evans Tokushima Fatty(OLETF) rats

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  • quantitative study of the optic nerve in diabetic mutant Otsuka Long Evans Tokushima Fatty OLETF rats

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<jats:p><jats:bold>ABSTRACT </jats:bold> Optic nerves of the Otsuka Long‐Evans Tokushima Fatty (OLETF) rat, an animal model of non‐insulin dependent diabetes mellitus, were examined using quantitative stereological procedures. At 67 weeks of age, OLETF rats showed a mild hyperglycemia: their blood glucose level was 196 ± 93 mg/dl, significantly higher than that of non‐diabetic control Long‐Evans Tokushima Otsuka (LETO) rats (110 ± 24 mg/dl). However, there were no differences in the cross sectional area of optic nerves (the mean minimum diameter), the total number and mean diameter of both myelinated and non‐myelinated fibers, or the thickness of the myelin sheath between OLETF and LETO rats. The results suggested that a mild hyperglycemia in OLETF rats could not cause any morphological changes in the optic nerve.</jats:p>

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