A quantitative study of the optic nerve in diabetic mutant, Otsuka Long-Evans Tokushima Fatty(OLETF) rats

Kazuhiko Sawada, Sachiko Nitta, Hiromi Sakata-Haga

doi:10.1111/j.1741-4520.2001.tb00840.x

A quantitative study of the optic nerve in diabetic mutant, Otsuka Long-Evans Tokushima Fatty(OLETF) rats

DOI Web Site Web Site Web Site 被引用文献1件参考文献37件

書誌事項

タイトル別名

quantitative study of the optic nerve in diabetic mutant Otsuka Long Evans Tokushima Fatty OLETF rats

この論文をさがす

説明

<jats:p><jats:bold>ABSTRACT </jats:bold> Optic nerves of the Otsuka Long‐Evans Tokushima Fatty (OLETF) rat, an animal model of non‐insulin dependent diabetes mellitus, were examined using quantitative stereological procedures. At 67 weeks of age, OLETF rats showed a mild hyperglycemia: their blood glucose level was 196 ± 93 mg/dl, significantly higher than that of non‐diabetic control Long‐Evans Tokushima Otsuka (LETO) rats (110 ± 24 mg/dl). However, there were no differences in the cross sectional area of optic nerves (the mean minimum diameter), the total number and mean diameter of both myelinated and non‐myelinated fibers, or the thickness of the myelin sheath between OLETF and LETO rats. The results suggested that a mild hyperglycemia in OLETF rats could not cause any morphological changes in the optic nerve.</jats:p>

収録刊行物

Congenital anomalies : the official journal of the Japanese Teratology Society

Congenital anomalies : the official journal of the Japanese Teratology Society 41 (4), 307-311, 2001

Kyoto : Japanese Teratology Society