Insights into the Biological Redox Chemistry of 2'-Deoxyadenosine 5'-Monophosphate by Electrochemical Techniques
Bibliographic Information
- Other Title
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- Insights into the Biological Redox Chemistry of 2 Deoxyadenosine 5 Monophosphate by Electrochemical Techniques
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Abstract
<jats:title>Abstract</jats:title> <jats:p>The electrochemical oxidation of 2′-deoxyadenosine 5′-monophosphate at a pyrolytic graphite electrode (PGE) was studied in the pH range 2.65–10.03 and was found to proceed in a single well-defined oxidation peak, Ia, over the entire pH range. The cyclic voltammetric behavior indicated the pH dependence of the oxidation pathway. The kinetic studies of the UV-absorbing intermediate generated during electrooxidation were followed spectrophotometrically, and decay occurred in a pseudo first-order reaction having k values in the range (0.595–0.986) × 10−3 s−1 over the entire pH range studied. Coulometric studies indicated that the process of the oxidative pathway involved n values as 5.0 ± 0.5 in the acidic range (pH 3.37) and 4.0 ± 0.5 at physiological pH 7.22. The products of electrooxidation were characterized by GC-MS and on the basis of electrochemical, spectrochemical, and product analysis; a plausible redox mechanism is suggested.</jats:p>
Journal
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 78 (11), 1944-1952, 2005
Tokyo : Chemical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1521417753463518592
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- NII Article ID
- 10016844957
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- NII Book ID
- AA00580132
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- ISSN
- 00092673
- 13480634
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- NDL BIB ID
- 7695596
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- Text Lang
- en
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- NDL Source Classification
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- ZP1(科学技術--化学・化学工業)
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- Data Source
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- NDL
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- CiNii Articles