Glutathione nanosphere: self-assembly of conformation-regulated trigonal-glutathiones in water
書誌事項
- タイトル別名
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- Glutathione nanosphere self assembly of conformation regulated trigonal glutathiones in water
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<jats:title>Abstract</jats:title> <jats:p>A novel trigonal conjugate of glutathiones with a 1,3,5-tris(aminomethyl)-2,4,6-triethylbenzene core was synthesized and its self-assembling behavior was investigated in water. Three glutathione units were regulated to orient on the same side of the benzene ring, through steric repulsions between ethyl groups attached on the benzene core. Concentration dependence of 1H NMR chemical shifts in D2O revealed formation of molecular assemblies with two affinity constants (Ka = 4.75 × 102 and 6.76 × 104 M−1), which reflect stepwise assembly directed by electrostatic interactions, hydrophobic interactions, and hydrogen bonding. In scanning electron microscopy, hard spherical assemblies with the size of 310 ± 50 nm were observed at high concentration (10 mM), whereas slightly disordered spherical assemblies were obtained at lower concentrations. The spherical assemblies self-assembled from the conformation-regulated trigonal glutathiones showed regular morphology and enhanced rigidity compared to those formed from conformationally non-regulated trigonal glutathiones.</jats:p>
収録刊行物
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 83 (8), 880-886, 2010-08
Tokyo : Chemical Society of Japan
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詳細情報 詳細情報について
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- CRID
- 1521417754962158720
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- NII論文ID
- 10026510259
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- NII書誌ID
- AA00580132
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- ISSN
- 00092673
- 13480634
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- NDL書誌ID
- 10779800
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- 本文言語コード
- en
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- NDL 雑誌分類
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- ZP1(科学技術--化学・化学工業)
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- データソース種別
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- NDL
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