Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis
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Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>Development of accurate methods for predicting progression of tuberculosis (TB) from the latent state is recognized as vitally important in controlling TB, because a majority of cases develop from latent infections. Past TB that has never been treated has a higher risk of progressing than does latent <jats:italic>Mycobacterium tuberculosis</jats:italic> infection in patients who have previously received treatment. Antibody responses against 23 kinds of <jats:italic>M. tuberculosis</jats:italic> proteins in individuals with past TB who had not been medicated were evaluated. These individuals had significantly higher concentrations of antibodies against Antigen 85A and mycobacterial DNA‐binding protein 1 (MDP1) than did those with active TB and uninfected controls. In addition, immunohistochemistry revealed colocalization of tubercle bacilli, antigen 85 and MDP1 inside tuberculous granuloma lesions in an asymptomatic subject, showing that <jats:italic>M. tuberculosis</jats:italic> in lesions expresses both antigen 85 and MDP1. Our study suggests the potential usefulness of measuring antibody responses to antigen 85A and MDP1 for assessing the risk of TB progression.</jats:p></jats:sec>
Journal
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- Microbiology and immunology / Japanese Society for Bacteriology, Japanese Society for Virology, Japanese Society for Host Defense Research
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Microbiology and immunology / Japanese Society for Bacteriology, Japanese Society for Virology, Japanese Society for Host Defense Research 57 (1), 30-37, 2013-01
Richmond : Blackwell Publishing Asia Pty
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Details 詳細情報について
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- CRID
- 1521699230042586368
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- NII Article ID
- 40019554362
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- NII Book ID
- AA00738350
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- ISSN
- 03855600
- 13480421
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- NDL BIB ID
- 024212528
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- Text Lang
- en
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- NDL Source Classification
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- ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
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- Data Source
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- NDL
- Crossref
- CiNii Articles
- KAKEN