Effect of the Electron Density of the Heme Fe Atom on the Fe-Histidine Coordination Bond in Deoxy Myoglobin
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<jats:title>Abstract</jats:title> <jats:p>The stretching frequency of the coordination bond between the heme Fe atom and proximal histidine (His93) Nε atom (νFe–His), and the NMR shift of the His93NδH proton (His93NδH shift) of the deoxy form of a hemoprotein have been used to determine the electronic nature of the His93 imidazole highly relevant to regulation of heme Fe reactivity. We determined the νFe–His values and His93NδH shifts of the deoxy forms of myoglobins reconstituted with artificial heme cofactors possessing strongly electron-withdrawing trifluoromethyl (CF3) group(s) as peripheral side chain(s). The study revealed that the bond between the heme Fe and His93 becomes stronger with increasing number of CF3 substitutions due to an increase in acidity of the His93NδH hydrogen bonded to the carbonyl O atom of Leu89. Thus, the present study demonstrated that the electronic nature of the His93 imidazole in deoxy Mb is affected by electronic perturbation induced by chemical modification of the heme cofactor.</jats:p>
収録刊行物
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 87 (8), 905-911, 2014-08
Tokyo : Chemical Society of Japan
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詳細情報 詳細情報について
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- CRID
- 1522825130327947904
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- NII論文ID
- 130004153305
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- NII書誌ID
- AA00580132
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- ISSN
- 00092673
- 13480634
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- NDL書誌ID
- 025633335
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- 本文言語コード
- en
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- NDL 雑誌分類
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- ZP1(科学技術--化学・化学工業)
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- データソース種別
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- NDL
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