The dopaminergic system in attention deficit/hyperactivity disorder
書誌事項
- タイトル別名
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- dopaminergic system in attention deficit hyperactivity disorder
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<jats:p><jats:bold>ABSTRACT </jats:bold> Numerous studies have shown the importance of the mesocorticolimbic dopamine system in the pathophysiology of attention deficit/hyperactivity disorder. However, there has been inconsistency in the findings of those studies. Varied and sometimes contradictory interpretation has been made on the basis of similar results. It is, therefore, still unclear whether the dopaminergic system is hypo‐ or hyperfunctioning in attention deficit/hyperactivity disorder. The majority of the functional brain imaging studies in both clinical and experimental settings support hypofunction of the basal ganglia which receive abundant dopaminergic afferent. The experimental studies, using dopamine‐depleted animals, also support the hypodopaminergic hypothesis, whereas recent studies with the dopamine transporter knockout/knockdown mouse suggest hyperdopaminergic function as the underlying abnormality. In this review we attempt to clarify the issues raised by previous neuroimaging and functional neuroimaging studies. Research involving animal models with genetic traits, genetic manipulation or with brain lesions is analysed, concentrating on the significance of the dopaminergic system in the abnormal behavior of attention deficit/hyperactivity disorder. In addition, the functional state of the dopaminergic system is considered through the speculated mechanism of psychostimulant therapy of the disorder. No final conclusions have been reached regarding the pathological, biochemical and physiological mechanisms responsible for various symptoms. Inconsistency in the findings and their interpretations may indicate the heterogeneity of the pathogenesis of this syndrome.</jats:p>
収録刊行物
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- Congenital anomalies : the official journal of the Japanese Teratology Society
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Congenital anomalies : the official journal of the Japanese Teratology Society 43 (2), 114-122, 2003
Kyoto : Japanese Teratology Society
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詳細情報 詳細情報について
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- CRID
- 1523106605815760640
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- NII論文ID
- 110002785607
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- NII書誌ID
- AN10066760
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- ISSN
- 09143505
- 17414520
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- NDL書誌ID
- 6648597
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- Web Site
- http://id.ndl.go.jp/bib/6648597
- https://ndlsearch.ndl.go.jp/books/R000000004-I6648597
- https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1741-4520.2003.tb01035.x
- https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1741-4520.2003.tb01035.x
- https://search.jamas.or.jp/link/ui/2004156051
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- 本文言語コード
- ja
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- NDL 雑誌分類
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- ZS32(科学技術--医学--小児科学・先天異常・奇形)
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- データソース種別
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- NDL
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