Comparative study of Mouse Trisomy 16 and bis-diamine treated fetuses: Discrimination of possible contribution of neural crest cells to malformations
書誌事項
- タイトル別名
-
- Comparative study of Mouse Trisomy 16 and bis diamine treated fetuses Discrimination of possible contribution of neural crest cells to malformations
この論文をさがす
抄録
<jats:p><jats:bold>ABSTRACT </jats:bold> In order to directly compare the malformation complex induced by genetic and environmental factors, mouse trisomy 16 (Ts 16) fetuses and bis‐diamine treated (BDT) mouse fetuses in which pregnant females were orally dosed with 3.0 mg and 1.0 mg/B.W. (g) bisdiamine eight hours apart on 9 days of pregnancy, were examined. Cystic hygroma with generalized edema appeared in most Ts 16 and in less than 50% of BDT fetuses. Blunt snout or facial cleft with aplasia or hypoplasia of the olfactory bulb was observed in BDT fetuses. The thymus was markedly to moderately hypoplastic in Ts 16, and absent or markedly hypoplastic in BDT fetuses. Parathyroid glands were inclined to be unsettled in relative location to the thyroid in Ts 16 and absent in BDT fetuses. Aortic arch abnormalities were present in approximately half of the cases of Ts 16 and in the majority of cases of BDT fetuses. In the conotruncal region, double outlet right ventricle and persistent truncus arteriosus were dominantly observed in Ts 16 and BDT fetuses, respectively. Atrioventricular septal defect was observed in every Ts 16 and in about 30% of BDT fetuses. These results indicate that not only environmental factors but also genetic factors can experimentally induce DiGeorge‐Iike anomaly in mice. Abnormal development relevant to neural crest cells seems to occur typically in BDT fetuses, and incompletely in Ts 16 fetuses.</jats:p>
収録刊行物
-
- Congenital anomalies : the official journal of the Japanese Teratology Society
-
Congenital anomalies : the official journal of the Japanese Teratology Society 41 (3), 169-176, 2001
Kyoto : Japanese Teratology Society
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1523669555020974592
-
- NII論文ID
- 110002785805
-
- NII書誌ID
- AN10066760
-
- ISSN
- 09143505
- 17414520
-
- NDL書誌ID
- 5988693
-
- 本文言語コード
- en
-
- NDL 雑誌分類
-
- ZS32(科学技術--医学--小児科学・先天異常・奇形)
-
- データソース種別
-
- NDL
- Crossref
- CiNii Articles