Silkworm as an experimental animal for research on fungal infections
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<jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>Silkworm, <jats:italic>Bombyx mori</jats:italic>, has various advantages as an experimental animal, such as the low cost for rearing and fewer ethical problems. Models utilizing silkworms of infection with pathogenic bacteria have been established for identification of genes encoding virulence factors by large‐scale <jats:italic>in vivo</jats:italic> screening. In this review, we describe recent progress in the study of silkworm infection models for elucidating the mechanisms of fungi infection. Silkworm infection models have been established for <jats:italic>Candida albicans</jats:italic>, <jats:italic>Candida tropicalis</jats:italic>, <jats:italic>Candida glabrata</jats:italic> and <jats:italic>Cryptococcus neoformans</jats:italic>, which are yeast type fungi, and <jats:italic>Aspergillus fumigatus</jats:italic>, <jats:italic>Arthroderma vanbreuseghemii</jats:italic>, <jats:italic>Arthroderma benhamiae</jats:italic>, <jats:italic>Microsporum canis</jats:italic>, <jats:italic>Trichophyton rubrum</jats:italic>, and <jats:italic>Rhizopus oryzae</jats:italic>, which are filamentous fungi. Novel genes encoding virulence factors in <jats:italic>C. albicans</jats:italic> and <jats:italic>C. glabrata</jats:italic> have been identified by using the silkworm infection models. We here outline the benefits of using silkworm infection models and a strategy for identifying the genes responsible for pathogenicity of microorganisms such as fungi. © 2019 The Authors. <jats:italic>Microbiology and Immunology</jats:italic> Published by The Societies and John Wiley & Sons Australia, Ltd.</jats:p></jats:sec>
収録刊行物
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- Microbiology and immunology / Japanese Society for Bacteriology, Japanese Society for Virology, Japanese Society for Host Defense Research
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Microbiology and immunology / Japanese Society for Bacteriology, Japanese Society for Virology, Japanese Society for Host Defense Research 63 (2), 41-50, 2019-02
Richmond : Blackwell Publishing Asia Pty
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詳細情報 詳細情報について
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- CRID
- 1523951030731104256
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- NII論文ID
- 40021840652
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- NII書誌ID
- AA00738350
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- ISSN
- 03855600
- 13480421
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- NDL書誌ID
- 029575558
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- 本文言語コード
- en
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- NDL 雑誌分類
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- ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
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- データソース種別
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- NDL
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