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<jats:title>Abstract</jats:title> <jats:p>The review focuses on the molecular design of artificial sequence-specific DNA-cleavers which have recently been developed in our laboratories. These include: DNA cleavers mimicking natural antitumor antibiotic like enediyne antibiotics, bleomycins, and kapurimycin A3. The design of photochemical DNA-cleaving molecules is also described. These are classified as: i) nonselective DNA cleavers, ii) thymine selective DNA cleavers, iii) photo-Fenton reagents, iv) photoinducible DNA alkylating agents, and v) DNA cleavers via photoinduced electrontransfer. The scope and limitation of these DNA-cleaving agents are described with a special emphasis on the concept and strategy for designing novel sequence-specific DNA cleavers, as well as on the mechanistic aspects of their DNA cleavage.</jats:p>
収録刊行物
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 69 (11), 3007-3019, 1996-11
Tokyo : Chemical Society of Japan
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詳細情報 詳細情報について
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- CRID
- 1524232505128557056
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- NII論文ID
- 10008910204
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- NII書誌ID
- AA00580132
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- ISSN
- 00092673
- 13480634
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- NDL書誌ID
- 4098838
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- 本文言語コード
- en
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- NDL 雑誌分類
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- ZP1(科学技術--化学・化学工業)
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- データソース種別
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- NDL
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