The Effect of Maltose Infusion on Amino Acid Composition of Maternal Venous Blood and Fetal Blood in Utero

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  • NISHIJIMA,Mitsushige
    Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine
  • IWATA,Mitsuru
    Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine

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  • マルトース投与による妊婦静脈血中および臍帯動静脈血中アミノ酸動態への影響

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A study was made of the possibility that the maltose infusion, which had good clinical results against intrauterine growth retardation, can change the amino acid composition in maternal and, or fetal blood. We have done a comparative study with maltose-infusion and non-infusion groups in spontaneous delivery. Amino acid, maltose, glucose, glutamine dehydrogenase (GLDH), isocitrate dehydrogenase (ICDH), gamma-glutamyl transpeptidase (GGTP) and blood urea nitrogen were analyzed in maternal venous (MV), umbilical venous (UV) and umbilical arterial blood (UA). The following results were obtained : 1) Blood glucose were significantly higher in MV and UV in the infusion group. 2) Maltose had a significant correlation only between UV and UA. 3) Glucose and maltose had no significant correlation. 4) Valine, tyrosine and ethanolamine were significantly lower in MV with infusion. 5) Aspartic acid in UA was significantly lower with infusion. 6) Phenylalanine in UV and UA were significantly higher with infusion. 7) Phenylalanine in UV had a significant correlation (r=-0.58) with the maltose level. 8) Activities of GLDH, ICDH, GGTP and BUN did not change significantly following maltose infusion. These results suggest that clinical efficiency of maltose infusion can be based not only the increased supply of glucose but also the efficient use of transported amino acid in the fetus.

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