Assessment of Serum Estrogen Levels by RIA with HPLC during Hormone Replacement Therapy
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- YASUI,Toshiyuki
- Department of Obstetrics and Gynecology, The University of Tokushima
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- UEMURA,Hirokazu
- Department of Obstetrics and Gynecology, The University of Tokushima
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- YONEDA,Naoto
- Department of Obstetrics and Gynecology, The University of Tokushima
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- IRAHARA,Minoru
- Department of Obstetrics and Gynecology, The University of Tokushima
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- AONO,Toshihiro
- Department of Obstetrics and Gynecology, The University of Tokushima
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- SUNAHARA,Satoshi
- Mitsubishi Kagaku Bio-Clinical Laboratories, INC.
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- HATA,Keishi
- Mitsubishi Kagaku Bio-Clinical Laboratories, INC.
Bibliographic Information
- Other Title
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- ホルモン補充療法における血中エストロゲン値の高感度測定法による検討
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Abstract
We studied the serum estradiol and estrone levels in 146 peri and postmenopausal women, and in 38 women who had complained of various climacteric disturbance symptoms during daily hormone replacement therapy (HRT) with conjugated equine estrogen (CEE) 0.625mg and medroxyprogesterone acetate (MPA) 2.5mg. Serum estradiol and estrone were measured before treatment, and at 6 months, and after one year of the HRT therapy by HPLC-radioimmunoassay. In 146 peri and postmenopausal women, the serum level of estradiol was from 3 to 6pg/ml. The serum level of estradiol in 38 women after HRT significantly increased (p<0.01) from 3.34 to 23.6pg/ml at 6 months, and 21.5pg/ml at 12 months. The serum level of estrone significantly increased (p<0.01) from 26.6pg/ml to 156.7pg/ml at 6 months, and 137.2pg/ml at 12 month. These results are very useful for deciding on the doses of hormones and the expected serum estradiol level in HRT for Japanese women.
Journal
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- 日本産科婦人科學會雜誌
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日本産科婦人科學會雜誌 47 (7), 655-661, 1995-07-01
日本産科婦人科学会
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Details 詳細情報について
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- CRID
- 1540009770382456064
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- NII Article ID
- 110002111397
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- NII Book ID
- AN00190060
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- Text Lang
- ja
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- Data Source
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- NDL-Digital
- CiNii Articles