Multicenter Study for Maternal Serum Triple Markers to Establish Japanese Standards

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  • 多施設共同研究による本邦における妊婦血清トリプルマーカー基準値設定の試み

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Objective: We evaluated triple markers (α-fetoprotein, free β-human chorionic gonadotropin, and unconjugated estriol) in the second trimester to establish Japanese standards. Methods: Serum samples were collected from 2,201 pregnant women between 12 and 20 weeks of gestation as a part of a multicenter prenatal diagnostis study. Median values of each marker were calculated from 1,641 unaffected pregnancies. Multiples of the median for each of the three markers were also calcu1ated for trisomy 21. Results: The mean age, gestational weeks and maternal body weight were 30.5 years, 14.9 weeks and 52.6kg, respectively. The median α-fetoprotein value increased from 18.1 ng/ml at 12 weeks of gestation to 85.55 ng/ml at 20weeks of gestation. The median uncojugated estriol value also increased from 0.35 ng/ml at 12 weeks of gestation to 3.34 ng/ml at 20 weeks of gestation, but the median value of free β-human chorionic gonadotropin decreased from 53.85 ng/ml to 9.95 ng/ml. Seven cases of trisomy 21 were included in our study. In all of these seven cases, the multiples of the median of α-fetoprotein were less than l.0 and those of free β-human chorionic gonadotropin were more than 2.0. The multiples of the median of unconjugated estliol were less than l.0 in six of them. Conclusion: The medians or Japanese triple markers were calculated from l,641 unaffected pregnancies in a multi center study.

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