High dose chemotherapy for two children with relapsed Wilms' tumor

  • KUSUKI,Shigenori
    Department of Pediatrics, Osaka University Graduate School of Medicine
  • TAKIZAWA,Sachiko
    Department of Pediatrics, Osaka University Graduate School of Medicine
  • TOKIMASA,Sadao
    Department of Pediatrics, Osaka University Graduate School of Medicine
  • HASHII,Yoshiko
    Department of Pediatrics, Osaka University Graduate School of Medicine
  • OHTA,Hideaki
    Department of Pediatrics, Osaka University Graduate School of Medicine
  • YONEDA,Akihiro
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine
  • FUKUZAWA,Masahiro
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine
  • KUSAFUKA,Takeshi
    Division of Pediatric Surgery, Department of Surgery, Nihon University School of Medicine
  • HARA,Junichi
    Department of Pediatric Hematology Oncology, Osaka City General Hospital
  • OZONO,Keiichi
    Department of Pediatrics, Osaka University Graduate School of Medicine

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Other Title
  • 再発Wilms腫瘍2例に対する大量化学療法

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Abstract

Two children with relapsed Wilms' tumor underwent high-dose chemotherapy consisting of thio-TEPA and L-PAM. The disease recurred at lung and mediastinal lymph nodes two months after completion of primary therapy in Patient 1, and at local lesion and lung during initial therapy in Patient 2. Patient 1, who later received irradiation to residual tumor, is free of disease four years and one month after relapse, and Patient 2 had marked reduction of tumor size by high-dose chemotherapy, suggesting effectiveness of high-dose chemotherapy for treatment of relapsed Wilms' tumor.

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