A Method to Predict Physical Incompatibility in Admixing Injections into Infusion (III)

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  • 輸液に混注する注射薬の配合変化予測法 : 第3報

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In previous studies, we have reported a method for calculation to predict pH values in admixing several injections into some infusions. The present study was designed to develop a better method of predicting physical incompatibility in admixing several injections into some infusions by using the background of our theoretical considerations. The results were as follows. It has been considered that the admixtures of bromhexine hydrochloride and hydrocortisone sodium phosphate were incompatible in any infusions. Whereas in our predictive method, it was shown that both of these injections were virtually compatible in some electrolyte solutions as Solita T-3, Physiosol-3 and Potacol R infusions. And it became possible to predict the changes in admixing potassium canrenoate injection into some infusions, which had been quite difficult to predict. In addition, we could clearly predict the case of being compatible by altering the order of admixing considered the buffering capacity of each injection. These results indicate that it will be more useful to predict the physical incompatibility in admixing several injections into some infusions than the other methods frequently used.

Journal

  • 病院薬学

    病院薬学 17 (3), 108-117, 1991-06-20

    日本病院薬剤師会

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