New Approach to Cell-free and Concentrated Ascites Reinfusion Therapy (CART) : A Preliminary Study of Washed-CART

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  • Eguchi,Kei
    Department of Clinical Engineering, Tokyo Women's Medical University
  • Yamamoto,Ken-ichiro
    Department of Clinical Engineering, Tokyo Women's Medical University
  • Minematsu,Yusuke
    Division of Clinical Engineering, National Hospital Organization Osaka National Hospital
  • Kaneko,Iwakazu
    Department of Clinical Engineering, Tokyo Women's Medical University
  • Akiba,Takashi
    Department of Blood Purification, Tokyo Women's Medical University
  • Mineshima,Michio
    Department of Clinical Engineering, Tokyo Women's Medical University

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Other Title
  • 新しい洗浄型CART(Washed-CART)の考案 : 基礎的検討

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These days, cell-free and concentrated ascites reinfusion therapy (CART) is aggressively performed for intractable ascites of hepatocirrhosis, cancer in Japan. However, adverse reactions such as fever have often occurred. In order to improve conventional CART, we developed a new CART system named "Washed-CART". In this system, we tried not only to remove cytokines from concentrated ascites but also to control their concentration with a washing process with saline. The reduction ratio of cytokine-like solutes with a molecular weight of 20-30 kDa increased by 20% or more through the washing process, while the albumin level remained almost the same. Pressure at the inlet of the filter strongly correlated with the albumin level of the concentrate, indicating the albumin level can be controlled by the pressure value. If a cryopreserve ascites system is developed in the future, the Washed-CART will prove effective for the system.

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