Compatibility of Ophthalmic Solutions : For the Treatment of Glaucoma and Cataract

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  • ENDO,MUTSUMI
    Department of Pharmacy, University of Tokyo Branch Hospital
  • YASUNO,NOBUHIRO
    Department of Pharmacy, University of Tokyo Branch Hospital
  • TANAGAMI,KAORI
    Department of Pharmacy, University of Tokyo Branch Hospital
  • ONDA,ASAKA
    Department of Pharmacy, University of Tokyo Branch Hospital
  • IMOTO,MIHO
    Department of Pharmacy, University of Tokyo Branch Hospital
  • IIDA,NAOMI
    Department of Pharmacy, University of Tokyo Branch Hospital
  • SEKINE,YUKO
    Department of Pharmacy, University of Tokyo Branch Hospital
  • MIYAZAKI,NORIO
    Department of Pharmacy, University of Tokyo Branch Hospital
  • WATANABE,SHIGEKAZU
    Department of Pharmacy, University of Tokyo Branch Hospital
  • NAKAMURA,YUKO
    Department of Pharmacy, University of Tokyo Branch Hospital
  • KUROKAWA,YOSUKE
    Department of Pharmacy, University of Tokyo Branch Hospital
  • TSUCHIYA,MASAO
    Department of Pharmacy, University of Tokyo Branch Hospital
  • ARAKAWA,YOSHIHIRO
    Department of Pharmacy, University of Tokyo Branch Hospital
  • ONO,HIDEKI
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo

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Other Title
  • 点眼剤の配合変化に関する検討 : 緑内障・白内障

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Abstract

We studied the compatibility in mixing any two of eight kinds of ophthalmic solutions which are frequently used in operations for glaucoma or cataract. Changes in the appearance, pH value, osmotic pressure and viscosity were checked immediately after mixing, both 1 hour and 24 hours after mixing and keeping in a dark place at room temperature. In some combinations, the mixture became turbid probably due to some of antiseptics to other ingredients. Regarding Noflo Ophthalmic Solution, white needle crystals were generated when mixed with some other drugs. These crystals were identified as norfloxacin (a principal ingredient of Noflo Ophthalmic Solution) by high-performance liquid chromatography and were found to be formed by the increase of pH. From these results, close attention should be paid to the order and intervals in the successive administration of various many ophthalmic solutions while taking into account not only any incompatlbility of the antiseptics as well as any changes in the pH values.

Journal

  • 病院薬学

    病院薬学 24 (3), 284-291, 1998-06-10

    日本病院薬剤師会

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