Hachimijiogan Having no Estrogenic Activity is Effective for Senile Colpitis

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  • エストロゲン活性を示さない八味地黄丸により,老人性膣炎の治療は可能か : その細胞学的,内分泌学的検討

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The effects of Hachimijiogan, a Chinese medicine, were studied in patients with senile colpitis. Eighty-eight postmenopausal patients, aged 42-76 years, were treated. Hachimijiogan was effective in 65 of 66 cases with abnormal discharge, 10 of 11 with pruritus vaginae and 60 of 62 with subepithelial hemorrhage. Overall more than ninety per cent of the patients responded well. The serum FSH, E_1 and E_2 levels were not statistically changed in this treatment. The vaginal Pap smear showed a significant decrease in parabasal type cells and an increase in intermediate type cells (p <0.01). Radioimrnunoassay of E_1, E_2, E_3, testosterone, FSH, LH and prolactin in Hachimijiogan were below the levels of sensitivity. These data suggest that Hachimijiogan is effective for senile colpitis and patients with senile colpitis associated with estrogen dependent tumors could be safely treated by Hachimijiogan.

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