Immunomodulating effects of polysaccharides isolated from herbal products :

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Abstract

Polysaccharides (PSs) have been isolated from herbs Angelicae Radix and Hoelen, and their immunomodulating effects studied. Angelica PS consisted mainly of glucose, galactose, rhamnose arabinose and galacturonic acid whereas Hoelen PS contained galactose, glucose, mannose and galacturonic acid. The mice injected with Angelica or Hoelen PS, 0.2-1.0 mg/dose, i.p. followed by administration of pneumococcal type 9V PS-protein conjugate, 5μg/dose, i.p. produced higher serum levels of 9V PS IgG and IgM Abs than the non-treated control group. The mice treated with plant PS showed more rapid bacterial clearance from blood after challenge with virulent type 19F pneumococci. In addition, in mice immunized with type 9V glycoconjugate the treatment of plant PS induced TNF-α 4.0 to 5.5 fold higher than the control group. In immunized mice treated with Hoelen PS, 2.3 fold higher INF-γ activity was induced. Moreover, in immunized mice treated with plant PS, the production of IL-2 was 1.5 to 3.9 fold higher, whereas IL-4 level increased 4.6 to 6.4 fold higher as compared with the control group. These results indicate that one of the mechanisms regarding the stimulating effects of plant PSs to protective immunity of bacterial glycoconjugate immunogen is through the enhancing activities of cytokines and immune responses. Application of plant PSs to bacterial glycoconjugate vaccines could provide more effective protective immunity for the prevention of pneumococcal infection.

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