Plastic Bag Developed to Sterilize Liquid Preparations for External Use by an Autoclave

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  • オートクレーブによる外用薬液滅菌用のプラスチックバッグの開発

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A plastic bag, which is composed of 3layers i.e. polypropyrene, nylon and polyester films, has been devised for sterilization of liquid preparations for external use by an autoclave. Physico-chemical tests such as heavy metal, nonvolatile residue and water vapor permeation were carried out to evaluate the suitability as a container for liquid preparations. The adsorption of chlorhexidine gluconate and benzalkonium chloride from aqueous solutions to the plastic bag was investigated. This bag was adopted for the requirements under physico-chemical tests for plastics. There was no decrease of chlorhexidine gluconate or benzalkonium chloride by adsorption to the plastic bag under autoclaving at 115℃ for 30min, and subsequent storage at room temperature for 4weeks. It was suggested that the newly-devised plastic bag was very useful for sterilization of liquid preparations in hospital pharmacy.

Journal

  • 病院薬学

    病院薬学 18 (3), 293-298, 1992-06-20

    日本病院薬剤師会

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