成分献血の生体に及ぼす影響 : 採血時の副作用および頻回献血者における各種検査データの検討

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  • Effect of Apheresis Donations on Donors : Investigation of Adverse Reactions and Laboratory Data of Repeat Donors

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Eleven years have passed since the adoption of apheresis donation in Japan. The main target of apheresis has become platelets, and the time needed for the donation has increased. The number of repeat donors has increased as well, leading us to examine the effect of apheresis on donors. The incidence of adverse reactions was examined in apheresis donors. Biochemical and hematological test data were compared between repeat donors and recently non-bled, matched (age and sex) donors. The incidence of vaso-vagal reactions was 0.69% (male 0.20%, female 1.57%). The incidence was high in first-time donors, young donors and donors with low body weight. Citrate reaction was only seen in plateletpheresis, and the incidence was 0.17% (male 0.06%, female 0.40%) . Significant differences between repeat donors and recently non-bled donors were observed in serum ferritin, Hb, Ht, MCV, leukocyte count and lymphocyte count in males, and serum ferritin, Hb, Ht and albumin in females. The cause of the decrease of those figures in repeat donors is blood used for laboratory tests or blood lost in devices rather than the blood drawn into the product itself. The improvement of devices and follow-up of repeat donors is necessary.

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