Anti-tumor effect of Chinese herbal medicines "Scutellaria barbata and Oldenlandia diffusa" on cancer cell lines and C3H-AVy mouse with spontaneous hepatocellular carcinoma

NDL Digital Collections 13 References
  • YU,Hsueh-chiu
    Department of Molecular Life Science 1, Tokai University School of Medicine
  • SUZUKI,Shihoko
    Department of Health Education, National Institute of Fitness and Sports in Kanoya
  • OKUBO,Tomoichi
    Department of Molecular Life Science 1, Tokai University School of Medicine
  • KAWASHIMA,Issei
    Department of Internal Medicine, PL Tokyo Health Care Center:Department of Morphology, Tokai University School of Medicine
  • TSUDA,Michio
    Department of Molecular Life Science 1, Tokai University School of Medicine
  • BORAI,N.EL
    Department of Molecular Life Science 1, Tokai University School of Medicine
  • YAMAMURA,Masaichi
    Department of Molecular Life Science 1, Tokai University School of Medicine

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Other Title
  • 半枝蓮と白花蛇舌草の癌細胞増殖抑制効果と自然発症肝腫瘍マウスの延命効果

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Scutellaria barbata (SB) and Oldenlandia diffusa (OD) have been used in traditional Chinese medicine for treating stomach, colon, liver, breast and ovarian tumors. The anti-tumorgenic effect of SB and OD was examined by various in vitro and in vivo experimental studies. The combined effect of SB and OD was examined to determine the anti-tumorgenic effect. Experiments were done in vitro on human breast tumor cell line MCF-7 and human prostatic adenocarcinoma cell line DU-145. For in vivo experiments, C3H-AVy mice with spontaneous hepatocellular carcinoma were used. It was found that the herbal extracts inhibited the proliferation of both cell lines as measured by the MTT assay. In the proliferation of both cell lines after addition of various concentrations of herbal extracts in the medium, 50 % inhibition was obtained with 1 % herbal extracts, and 80 % inhibition by 10 % herbal extracts. C3H-AVy mice survived 1.4 times longer than controls after oral administration of the herbal extracts. In conclusion, the present in vivo and in vitro results strongly suggest that the conbination of OD and SB suppresses tumor growth in vitro and increases survival rate in mice with spontenous hepatocellular carcinoma.

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