家兎におけるクロルプロパミドの尿細管分泌に及ぼすシメチジンの阻害効果 (第2報)

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書誌事項

タイトル別名
  • Inhibitory Effects of Cimetidine on Renal Tubular Secretion of Chlorpropamide in Rabbits II

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説明

Effects of treatment of cimetidine (CMT) on pharmacokinetic behaviors of chlopropamide (CPA), an oral hypoglycemic agent, were investigated in rabbits with the standard renal clearance method. The renal clearance ratio and the renal tubular secretion volume of CPA were found to be markedly decreased by the treatment of CMT. Furthermore, the results of experiments using renal cortical slices demonstrated that CMT of the cationic drug decreased the accumlation of CPA. Inhibition of uptake by 2,4-dinitrophenol indicated an energy dependence. Probenecid, a competitor for the anion transport mechanism, moderately inhibited CPA uptake. These observations indicate that the treatment of CMT may depress the renal excretion of CPA by inhibiting the tubular secretion.

収録刊行物

  • 病院薬学

    病院薬学 20 (1), 17-23, 1994-02-20

    日本病院薬剤師会

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