A Clinical Study on Memory Function in Climacteric and Periclimacteric Women

  • OHKURA,Takeyoshi
    Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine
  • ISSE,Kunihiro
    Department of Psychiatry, Tokyo Metropolitan Tama Geriatric Hospital
  • WATABE,Hideki
    Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine
  • SEGAWA,Yushi
    Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine
  • MITSUYA,Kazuhiro
    Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine
  • ENOMOTO,Hideo
    Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine
  • HAYASHI,Masatoshi
    Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine
  • YAOI,Yoshimasa
    Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine

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Other Title
  • 更年期及びその周辺婦人の記憶機能に関する臨床的研究

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This study was designed to investigate memory function in climacteric and periclimacteric women who lived a normal, ordinary life. Two hundred women treated at the gynecological outpatient clinic of Koshigaya Hospital were divided into 7 groups: groups A (31~35yr), B (36~40yr), C (41~45yr), D (46~50yr), E (51~55yr), F (56~60yr) and G (61~65yr). Each group consisted of 30 women except group G (n=20). The memory function of each group was determined and the mean scores for 10 paired hard-associates after three trials of presentation were compared. The mean scores (±SD) for groups A and B were 8.0±2.0 and 8.2±1.7, respectively, which were not statistically different. The scores for both groups were significantly higher than those for the other groups (p<0.01). The mean scores for groups C and D were 5.9±2.1 and 5.6±2.4, respectively, which were not statistically different. The score for group C was significantly higher than those for groups E (4.5±2.4), F (4.2±2.2), and G (3.3±1.6) (p<0.05). The score for group D was significantly higher than those for groups F and G (p<0.05). The score for group E was significantly higher than that for group G (p<0.01). The decrease in memory function was the greatest in group C. In the climacterium, memory impairment was also observdd in group E. The former corresponds to the climacteric commencement age group where cyclic changes in serum estrogen levels decrease or cease, and the latter corresponds to the age group for menopause. Memory impairment progressed gradually in postclimacteric women.

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