Anaplastic Large Cell Lymphoma with Spike Fever and Osetolytic Lesion

NDL Digital Collections 13 References
  • UEDA,Satoshi
    Department of Pediatrics, Kinki University School of Medicine
  • SAKATA,Naoki
    Department of Pediatrics, Kinki University School of Medicine
  • IKEDA,Terumasa
    Department of Orthopaedic Surgery Kinki University School of Medicine
  • SIMONO,Taro
    Department of Radiology Kinki University School of Medicine
  • DOTE,Kensaku
    Department of Pathology Kinki University School of Medicine
  • KUWAE,Yuko
    Department of Pathology, Osaka Medical Center and Research Institute for Maternal and Child Health
  • NAKAYAMA,Masahiro
    大阪府立母子保健総合医療センター病理
  • YAGI,Makoto
    Department of Surgery Kinki University School of Medicine
  • HAMANISI,Tiaki
    Department of Orthopaedic Surgery Kinki University School of Medicine
  • TAKEMURA,Tukasa
    Department of Pediatrics, Kinki University School of Medicine

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Other Title
  • 2か月にわたる弛張熱と骨融解所見が先行したAnaplastic Large Cell Lymphoma(ALCL)の1例

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Description

We encountered an example of a diagnosis of anaplastic large cell lymphoma (ALCL), i.e. a fourteen-year-old-boy with persistent spike fever for 2 months who was found to have an osteolytic lesion. At the time of admission, when the first biopsy was performed, an osteolytic lesion in his lumbar vertebra (L1) was revealed, and the finding was a pathological diagnosis of osteomyelitis. Then, as the high fever still persisted with increasing serum levels of C-reactive proteins and the soluble form IL-2 receptor despite performing antibiotic therapy, a second examination was carried out 2 months later and found additional osteolytic lesions located in the right ilium and lymphadenopathy in the pelvic cavity. The second biopsy specimens from the lymphadenopathy were positive for CD30 and anapestic lymphoma kinase. Chemotherapy, which was conducted according to ALCL99, resolved his symptoms. At the time of admission, IL-6 was high, hypercytokinemia, spike fever and bone lesions occurring before ALCL developed. Therefore, these findings suggest that the prior occurrence of hypercytokinemia such as IL-6 plays an important role in the development of ALCL.

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