A Light and Electron Microscopic Study of Miillerlan Adenoibroma of the Uterus

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  • IWAI,Masazumi
    Department of Obstetrics and Gynecology School of Medicine Kyoto University
  • K0NISHI,Ikuo
    Department of Obstetrics and Gynecology School of Medicine Kyoto University
  • FUJII,Shingo
    Department of Obstetrics and Gynecology School of Medicine Kyoto University
  • KAWAGUCHl,Kanetoshi
    Department of Obstetrics and Gynecology School of Medicine Kyoto University
  • OKAMURA,Hitoshi
    Department of Obstetrics and Gynecology School of Medicine Kyoto University
  • SUZUKI,Akira
    Department of Obstetrics and Gynecology School of Medicine Kyoto University

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  • 子宮に発生したmunerian adenoibromaの組織学的検討

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Abstract

Mullerian adenofibroma composed of both histologically benign epithilia and benign mesenchyme is considered to be a rare entity of mixed mullerian tumor. A case of mullerian adenofibroma of the uterus was studied by light and electron microscopy. Light microscopically, the cleft like glands lined by single layered columnar or cuboidal epithelial cells were distributed in the proliferation of surrounding fibroblast like mesenchymal cells. Mitotic figures of mesenchymal cells were less than 1～2 in 10 high power fields, and no nuclear atypia or heterologous elements were observed. Electron microscopically, the epithelial cells had well developed mitochondria, r-ERs, tonofilaments in the cytoplasm, and short microbilli or cilia protruding into the lumen. In the mesenchyme, two types of cells were observed. One was spindle shaped cells resembling fibroblasts, and the other was cells resembling immature smooth muscle cells. The histological and ultrastructural features of mullerian adenofibroma were felt to resemble those of mullerian adenosarcoma, which may pursue a clinically malignant course. These findings suggest that mullerian adenofibroma and adenosarcoma may be in the common spectrum of mixed mullerian tumor.

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