Compatibility of Wintermin^<[○!R]> Fine Granules and Magnesium Oxide

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  • INADA,SETSUKO
    Department of Pharmacy, Kyoto Prefectural University of Medicine, Attached Hospital
  • OKADA,KOJI
    Department of Pharmacy, Kyoto Prefectural University of Medicine, Attached Hospital
  • OHTA,TOSIO
    Department of Pharmacy, Kyoto Prefectural University of Medicine, Attached Hospital
  • NISIDA,KATSUJI
    Department of Pharmacy, Kyoto Prefectural University of Medicine, Attached Hospital
  • MIZUNO,MASANAO
    Department of Pharmacy, Kyoto Prefectural University of Medicine, Attached Hospital

Bibliographic Information

Other Title
  • ウインタミン^<[○!R]>細粒と酸化マグネシウムの配合変化

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Description

The compatibility of Wintermin^<[○!R]> fine granules consisting of chlorpromazine phenolphthalinate and magnesium oxide was investigated by sensory test, and the residual amount of chlorpromazine was measured with high-performance liquid chromatography. Although the coloration to pink in the preparation was observed after preservation under medium (20℃, RH75%) and severe (30℃, RH92%) conditions, no change in the amount of chlorpromazine under any condition tested was noticed. It was also found from the chromatogram that a slight amount of phenolphthalein was contaminated in Wintermin^<[○!R]> fine granules. Moreover, no change was detected in the compatibility test of chlorpromazine hydrochloride and magnesium oxide under the severe condition. It was, therefore, suggested that the interaction between phenolphthalein and magnesium oxide alkalized by moisture was responsible for the coloration in the preparation of Wintermin^<[○!R]> fine granules and magnesium oxide.

Journal

  • 病院薬学

    病院薬学 16 (2), 107-111, 1990-04-20

    日本病院薬剤師会

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