Studies of 17β-hydroxysteroid-dehydrogenase Activity in Human Uterine Cervix

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  • TAKAHASHI,Shirou
    Department of Obstetrics and Gynecology, Okayama University Medical School

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  • ヒト子宮頚部における17β-hydroxysteroid-dehydrogenase活性の研究

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Abstract

The kinetics of 17β-hydroxysteroid-dehydrogenase (17β-HSD) activity in the human uterine cervix were determined, as were its localization in cervical tissues and the changes in two phases of the menstrual cycle. The Km value for 17β-HSD calculated by a Lineweaver-Burk's plot, was 2.0μM. The 17β-HSD activities in columnar epithelium, squamous epithelium and connective tissue in the proliferative phase were 49.1±8.9 (p mol/mg protein/hour), 16.5±2.3, and 9.0±1.0 (mean±SE) (n=5), respectively. In the secretory phase, the 17β-HSD activity in each site was 42.8±6.6, 12.2±3.1, and 10.6±1.6 (n=6), respectively. Thus, the 17β-HSD activity was significantly higher in the columnar epithelium (p<0.01) than in the other two sites, but there was no significant difference between the activity in the secretory and proliferative phases during menstruation.

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