The Plasticity of Somatic Stem Cells and Embryonic Stem Cells(Special Issue on "Stem Cell Biology and Tissue Regeneration")

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  • ATSUMI,Tadao
    Laboratory of Molecular Cell Science, The Institute of Physical and Chemical Research (RIKEN)(Special Issue on "Stem Cell Biology and Tissue Regeneration")

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  • 体性幹細胞の可塑性とES細胞(<特集>幹細胞生物学と組織再生)

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There have been accumulated the evidences that tissue-specific somatic stem cells have a greater capacity for differentiation than we had been expected. Among them, neural stem cells (NS cells) were reported to differentiate into various types of somatic cells other than neural cells after they were injected into adult hosts or blastocysts. To realize the mechanisms, by which they differentiated into non-neural cells, we established an in vitro system for the adipogenic differentitation of brain-derived NS cells. In this, NS cells differentiated into adipocytes via unidentifiable epithelial cells (MS cells). We speculate MS cells may be multipotent somatic stem cells capable of differentiating into both neural cells and non-neural cells.

Journal

  • Connective tissue

    Connective tissue 33 (4), 309-314, 2001-12-25

    日本結合組織学会

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