Salt-Amino Acid Coprecipitation Method

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  • Ogawa,Hiroshi
    Department of Internal Medicine, Shinseikai Dai-ichi Hospital

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  • 塩析

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A precipitant containing NaCl and glysine was mixed with the immunoglobulin of a patient's plasma in a column, and the precipitates were removed with an eliminating filter. A dialyzer was used to dialyze the supernates, and the dialyzed plasma component was added as a plasma supplement at the next plasma pheresis (PP) regimen. This, like PP therapy, was developed by Termo, Japan, and called the salt-amino acid coprecipitation (SAC) method. The SAC method showed a significantly higher removal rate of lgA and lgG than the double-filtration (DF) method. No albumin supplement was required from the second PP regimen. SAC is a significant and effective PP method.

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