Study on the Neuroendocrinological Control of Prolactin Release in Early Puerperium

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  • Kubota,Toshiro
    Department of Obstetrics and Gynecology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo
  • Kamata,Shusaku
    Department of Obstetrics and Gynecology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo
  • Tsuzuki,Hiroo
    Department of Obstetrics and Gynecology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo
  • Tei,Anson
    Department of Obstetrics and Gynecology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo
  • Saito,Motoi
    Department of Obstetrics and Gynecology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo

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  • ヒト産褥初期における Prolactin 分泌の神経内分泌調節機構に関する研究

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Abstract

The purpose of this study is to investigate the neuroendocrinological control mechanism of prolactin(PRL) acting on the hypothalamo-pituitary axis during early puerperium. The puerperal women consisted of three group:the breast-feeding group(n=39),the bromocriptine(BRC)-treated group(5mg/day,n=17) and naloxone-treated group(1mg iv,n=16). In each group,10mg metoclopramide(MCP), 500μg TRH or 400mg cimetidine was given intravenously. 1) The plasma PRL levels increased significantly after the injection of MCP,TRH and cimetidine. The peak values of ΔPRL levels were 447.0±62.3ng/ml after MCP,278.3±65.1ng/ml after TRH and 86.5±27.3ng/ml after cimetidine. 2) This PRL increase after the injection of MCP and cimetidine was suppressed significantly by pretreatment with BRC. However,the PRL increase after TRH was not suppressed by pretreatment with BRC. 3) Naloxone had no significant effect on PRL response to MCP and TRH,since the plasma PRL levels rose significantly after the injection of MCP and TRH in the naloxone-treated group. These results revealed that there were different mechanisms of PRL release in MCP and TRH. Furthermore,the PRL releasing mechanism was influenced by histamine H_2-receptor,but was not influenced by opioid peptide in early puerperium.

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