Correlation between Breast Development and Hormone Profiles in Puberal Girls

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  • MURAKAMI,Motoi
    Department of Obstetrics and Gynecology, Showa University School of Medicine
  • KAWAI,Kiyofumi
    Department of Obstetrics and Gynecology, Showa University School of Medicine
  • HIGUCHI,Kazumi
    Department of Obstetrics and Gynecology, Showa University School of Medicine
  • YANAIHARA,Takumi
    Department of Obstetrics and Gynecology, Showa University School of Medicine
  • ARAKI,Hidenosuke
    Department of Obstetrics and Gynecology, Showa University School of Medicine
  • NAKAYAMA,Tetsuya
    Department of Obstetrics and Gynecology, Showa University School of Medicine

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  • 思春期女子乳房発育とその内分泌学的背景

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In order to examine the relation between breast development and hormone levels, serum levels of hormones including LH, FSH, PRL, progesterone, 17αOH-progesterone, estradiol (E_2), pregnenolone, pregnenolone-sulfate, 17αOH-pregnenolone, cortisol, dehydroepiandrosterone (DHA), dehydroepiandrosterone-sulfate (DHA-S), testosterone and Δ^4-androstenedione were measured by RIA in 162 puberal girls aged 9 to 17 years. Height and body weight were also measured. Stages of breast development were classified into B_1 to B_5 according to Tanner et al. Results were as follow ; 1) Both body weight and height increased as the breast stage advanced during puberty. 2) The correlation with the concentration of hormone such as LH, FSH, E_2, DHA, DHA-S and T, and breast development was noticed during the puberal stage before the onset of menarche. A significant positive correlation was observed between DHA-S, body weight and each stage of breast development before and after the onset of menarche. From the results obtained above, the intimate relationship between breast development and steroid concentrations especially the adrenal steroid DHA-S was suggested.

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