The influence of formula Ma-Huang-Fu-Zi-Xi-Xin-Tang (Mao-bushi-saishin-to ;Mbst) on the results of urodynamic studies :

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Objective: We showed that an ephedrine-containing Kampo medicine does not worsen urodynamic studies in younger and elderly persons, although ephedrine has sympathomimetic effects in pharmacology. Method: A crossover trial on the effect of urodynamic study by Ma-Huang-Fu-Zi-Xi-Xin-Tang capsules (Mbst) and placebo (P) capsules based on the results of urodynamic studies was performed with 13 younger volunteers (38.0 ± 6 0, range 31-47). The mean prostate gland weight of the subjects was 15.6 ± 6.9g. Mbst was prepared as an example of an ephedrine containing drug. Uroflowgraphy was performed before Mbst or P administration and 3 hours after administration. The peak flow (Qmax), average flow (Qave), and voiding efficiency ε=Qave/Qmax. After we had checked the safety of performing this experiment with asymptomatic volunteers by performing the above experiments, we compared the urodynamic studies before and after administration of Mbst in elderly persons. Results: The ε=Qave/Qmax after administration of Mbst or P was 0.66 ± 0.08 or 0.65 ± 0.09, respectively. Qmax and Qave showed no statistical differentiations respectively. Thus, no effect of the medicine was revealed for any end-points. The statistical power of ε=Qave/Qmax was 99%, compared to 45% for Qmax and 42% for Qave, which means that ε=Qave/Qmax appeared to be one of the strongest indicators for urinate disturbances. Conclusion: Ephedrine containing Mbst was found to have little effect statistically on uroflowgraphy to have not only in younger subjects but also in elderly subjects. In addition, voiding efficiency ε=Qave/Qmax is a useful factor in the evaluation of urethral stenosis.

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