Extracellular Matrix Formed by MC3T3-E1 Osteoblast-Like Cells Cultured on Titanium : II. Collagen Fiber Formation :

NDLデジタルコレクション 参考文献21件
  • EGUCHI,Satoru
    Department of Dental Anesthesiology, University of Tokushima School of Dentistry
  • YAMASHITA,Kikuji
    Department of Anatomy, University of Tokushima School of Dentistry
  • MORIMOTO,Hiroyuki
    Department of Anatomy, University of Tokushima School of Dentistry
  • ICHIKAWA,Tetsuo
    Department of Removable Prosthodontics, University of Tokushima School of Dentistry
  • NAKAJO,Nobuyoshi
    Department of Dental Anesthesiology, University of Tokushima School of Dentistry
  • KITAMURA,Seiichiro
    Department of Anatomy, University of Tokushima School of Dentistry

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説明

Many aspects of the structures formed between titanium and cells and the mechanism of the formation are still unknown. In order to clarify these issues, we analyzed the initial structures formed between titanium and MC3T3-E1 osteoblast-like cells cultured on titanium. The present results indicate that extracellular matrix containing collagen fibers formed at the surface of a calcined layer on the titanium. At first, a hemispherical body and a small secondary spherical structure formed at the surface, followed by more beads to form a string-of-beads structure. These string-of-beads collagen structures elongated and formed spirals. For the first time ever, we directly observed the structure of collagen fiber formed between cultured osteoblasts and titanium with microscopy. Here, we describe the formation mechanism of type I collagen fibers in extracellular bone matrix. Elucidation of the mechanism of collagen fiber formation will aid in the development of controlled tissue regeneration.

収録刊行物

  • Connective tissue

    Connective tissue 36 (1), 9-15, 2004-04-08

    日本結合組織学会

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