Effects of Menopause and Hormone Replacement Therapy on the Metabolism of Remnant Lipoprotein

SANADA,Mitsuhiro, NAKAGAWA,Hitoshi, KODAMA,Ichiro, SAKASHITA,Tomohisa, OHAMA,Koso

Remnanto lipoprotein is a triglyceride (TG) rich lipoprotein which is a hydrolyzed product of chyromicron and very low density lipoprotein and has an atherogenic propensity. This study was aimed at elucidating the effect of monopause and hormone replacement therapy (HRT) on the metabolizm of remnant lipoprotein. The subjects were 20 premenopausal, 30 surgically menopausal and 40 postmenopausal women. In them were measured remnant-like particles of choresterol (RLP-C) which is known to act as an indicator of the remnant lipoprotein level in blood. And then 21 surgically menopausal women started on HRT with continuous conjugated estrogen (CEE) 0.625mg/day, and 30 postmenopausal women with a combination of CEE plus medrozyprogesterone acetate (MPA)2.5mg/day. Serum common lipids and RLP-C were measured after HRT. Serum RLP-C levels in surgically menopausal and postmenopausal women were significantly higher than in premenopausal women (p<0.005). Serum TC and LDL-C levels were decreased significantly (p<0.01) and HDL-C was increased significantly (p<0.01) by HRT in both groups, Serum TG levels were not changed, but those of RLP-C were decreased in both groups. The decrease in serum RLP-C levels in postmenopausal women was significant (p<0.05). In this study we confirmed that the level of RLP-C becomes higher after menopause, and it may be concluded that HRT which not only improves disturbances in lipoprotein metabolism but also exerts a favorable effect on remnant metabolism has the potential to prevent the development of arteriosclerosis.

Effects of Menopause and Hormone Replacement Therapy on the Metabolism of Remnant Lipoprotein

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