SAMPLE SIZE DETERMINATION BASED ON MID-P VALUE FOR USE WITH THE TESTING IN 2×2 COMPARATIVE TRIALS : To the memory of the late Professor Kazumasa Wakimoto

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Abstract

In testing two binomial probabilities Fisher's exact test is known to be too conservative. As a consequence, it requires a large sample size than expected to detect statistical significance. The use of mid-P value instead of the ordinary P-value in the testing would be one possibility to resolve such conservatism. This article investigates how much sample size can be reduced by adopting the mid-P value. It is shown that the sample sizes are almost comparable to those of unconditional tests. A table of sample sizes is given for the reasonable range of parameters to achieve the power of 0.8 or more when the significance level is 0.05.

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Details

  • CRID
    1570291226977200512
  • NII Article ID
    110001235611
  • NII Book ID
    AA10823693
  • ISSN
    09152350
  • Text Lang
    en
  • Data Source
    • CiNii Articles

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