Biopharmaceutical Studies of Thiazide Diuretics. III. : In Vivo Formation of 2-Amino-4-chloro-m-benzenedisulfonamide as a Metabolite of Hydrochlorothiazide in a Patient(Pharmaceutical)
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- OKUDA TERUAKI
- Faculty of Pharmaceutical Sciences, Osaka University
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- ITOH SOICHI
- Faculty of Pharmaceutical Sciences, Osaka University
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- YAMAZAKI MASARU
- Faculty of Pharmaceutical Sciences, Osaka University
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- NAKAHAMA HAJIME
- First Department of Internal Medicine, Osaka university Medical School
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- FUKUHARA YOSHIFUMI
- First Department of Internal Medicine, Osaka university Medical School
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- ORITA YOSHIMASA
- First Department of Internal Medicine, Osaka university Medical School
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説明
Urine, plasma and erythrocytes from a patient receiving hydrochlorothiazide were examined by high-performance liquid chromatography. The urine and erythrocyte showed an unknown peak in the chromatograms. This substance was identified as 2-amino-4-chloro-m-benzenedisulfonamide and the identification was confirmed by comparison of the substance with an authentic sample obtained by synthesis. All data were analyzed with a PC 9801VM computer in conjunction with a JASCO MULTI-320 multi-wavelength ultraviolet detector.
収録刊行物
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 35 (8), 3516-3518, 1987-08-25
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詳細情報 詳細情報について
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- CRID
- 1570291227372633728
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- NII論文ID
- 110006281445
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles
