Synthesis and Gastroprokinetic Activity of 2-Amino-N-[(4-benzyl-2-morpholinyl) methyl] benzamide Derivatives
-
- 賀登 志朗
- Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
-
- 森江 俊哉
- Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
-
- 大野 一教
- Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
-
- 吉田 直之
- Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
-
- 吉田 豊吉
- Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
-
- 成戸 俊介
- Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
この論文をさがす
説明
2-Alkoxy-4-amino-N-[(4-benzyl-2-morpholinyl)methyl]-5-chlorobenzamides had been identified as the interesting members of a series of selective and potent gastroprokinetic agents. A new series of 2-amino- and 2-(substituted amino)-N-[(4-benzyl-2-morpholinyl)methyl]benzamides (13-35) has been synthesized and these compounds were examined to determine whether they have advantages over the 2-morpholinyl benzamides 1 with a 2-alkoxy group.The gastroprokinetic activity was generally reduced, but several compounds showed relatively potent activity, comparable to that of the standard agent, metoclopramide. N-[(4-Benzyl-2-morpholinyl)methyl]-4-chloro-2-[(4-chlorobenzoyl)amino]benzamide (32) showed the most potent activity in this series.
収録刊行物
-
- Chemical & pharmaceutical bulletin
-
Chemical & pharmaceutical bulletin 43 (4), 582-587, 1995-04-15
公益社団法人日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1570291227417369984
-
- NII論文ID
- 110003631521
-
- NII書誌ID
- AA00602100
-
- ISSN
- 00092363
-
- 本文言語コード
- en
-
- データソース種別
-
- CiNii Articles