The circadian change of gluconeogenesis in the liver in vivo in fed rats.

J-STAGE
  • KIDA Kaichi
    Department of Pediatrics, Ehime University School of Medicine
  • NISHIO Takashi
    Division of Protein Metabolism, Institute for Protein Research, Osaka University
  • YOKOZAWA Takako
    Division of Protein Metabolism, Institute for Protein Research, Osaka University
  • NAGAI Katsuya
    Division of Protein Metabolism, Institute for Protein Research, Osaka University
  • MATSUDA Hiroshi
    Department of Pediatrics, Ehime University School of Medicine
  • NAKAGAWA Hachiro
    Division of Protein Metabolism, Institute for Protein Research, Osaka University

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説明

The circadian change of gluconeogenesis in the liver in vivo in fed rats was studied. Gluconeogenesis in the liver in vivo was determined by measuring the rate of synthesis of 14C-labeled blood glucose derived from a 14C-labeled substrate, such as lactate, pyruvate or an amino acid injected into nephrectomized rats. Gluconeogenesis in the liver from all substrates examined except glutamine was higher at 8:00 P. M. than at 8:00 A. M. in correspondence with the circadian rhythm of the activity of hepatic phosphoenolpyruvate carboxykinase. These data indicate that hepatic gluconeogenesis shows a circadian change in response to changes in nutritional conditions in vivo.

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