Successful Treatment with Octreotide for Intestinal Pseudoobstruction in Two Patients with Systemic Sclerosis

J-STAGE
  • Sugawara Nobuyuki
    Department of Dermatology, Gunma University Graduate School of Medicine
  • Abe Masatoshi
    Department of Dermatology, Gunma University Graduate School of Medicine
  • Tamura Atsushi
    Department of Dermatology, Gunma University Graduate School of Medicine
  • Kambe Naotomo
    Department of Dermatology, Kyoto University Graduate School of Medicine
  • Ishikawa Osamu
    Department of Dermatology, Gunma University Graduate School of Medicine

Bibliographic Information

Other Title
  • オクトレオチドが奏効した全身性強皮症に伴う偽性腸閉塞の２例

Abstract

The somatostatin analogue, octreotide, has been proposed as a promising therapeutic agent for abnormal gastrointestinal motility. We here in reported two cases of systemic sclerosis associated with massive pseudoobstruction, in which octreotide administration was efficacious agonist against gastrointestinal symptoms. Treatment with subcutaneous injection, octreotide 100μg daily, remarkably relieved the symptoms of pseudoobstruction. Thereafter, the interval of the injection was gradually prolonged to biweekly administration as a maintenance therapy. The treatment was well tolerated and able to maintain the digestive functions for a long period. The treatment with octreotide may be worth trying to improve clinical symptoms of pseudoobstruction in patients with systemic sclerosis.

Journal

  • Skin research

    Skin research 2 (5), 453-457, 2003

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

Keywords

Details 詳細情報について

Report a problem

Back to top