Acquired von Willebrand disease after Epstein-Barr virus infection

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mune globulin were given. Moreover, a repeated endoscopic examination 14 days after oral immune globulin treatment showed no evidence of residual cryptosporidial infection. The details of the normal immune response to cryptosporidial infestation remain unclear. The occurrence of chronic infection in patients with acquired immunodeficiency syndrome suggests that cellular immunity is important, but there is little definitive information in this regard. Acute cryptosporidial infection is accompanied by the appearance of IgM and IgG serum antibody to the organism.1~ The important role of antibody in the normal immune response is suggested by several reports of chronic cryptosporidial infection in children with congenital immunoglobulin deficiency but intact cellular immunity. 3, 4, 7 Seroepidemiologic studies indicate that 30% to 80% of healthy adults have serum antibody to CryptosporidiumJ 1' 12 It is thus likely that commercially available human serum immune globulin preparations contain substantial quantities of IgG antibody to Cryptosporidium. This IgG may be a valuable source of passive immunity in patients with chronic cryptosporidial infection. We conclude that a possible diagnosis of cryptosporidial infection should be considered in any immunocompromised child with chronic diarrhea. In addition, orally administered human serum immune globulin appears to be effective therapy for patients with chronic cryptosporidial infection.

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  • J Pediatr

    J Pediatr 119 595-598, 1991

    Elsevier BV

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