Animal Study of Simple Deep Hypothermia with Phentolamine or Nitroglycerin

  • Honda Nobuyoshi
    Department of Anesthesiology, Kitasato University School of Medicine

Bibliographic Information

Other Title
  • フェントラミン,ニトログリセリンを用いた低体温麻酔の基礎的研究

Search this article

Description

The effect of phentolamine and nitroglycerin on myocardial irritability was studied during simple deep hypothermia. Fifteen mongrel dogs were divided into three groups : five dogs were in a control group without any vasodilator, five were in a phentolamine group and the rest were a nitroglycerin group. Phentolamine completely prevented any kind of arrhythmia which appeared in every subject of the control group. Nitroglycerin decreased the myocardial irritability though not completely. Phentolamine acted as a powerful vasodilator during deep hypothermia (22℃) ; There was no compromise in cardiac output, total peripheral resistance did not increase, nor did pulmonary vascular resistance. Hemoconcentration was avoided. Hypopotassemia and higher catecholamine level were observed in the phentolamine group ; therefore, it seemed that ventricular fibrilation during deep hypothermia occurred independent of the level of the potassium or the catecholamine. Since nitroglycerin did not act as a powerful vaodilator during deep hypothermia, its antiarrhythmic effect was not so satisfactory as that of phentolamine.

Journal

  • Kitasato medicine

    Kitasato medicine 14 (3), 162-170, 1984-06-30

    Kitasato University

Keywords

Details 詳細情報について

Report a problem

Back to top