Synthesis of Some Polyhydroxylated Pyrrolidine Derivatives(Organic,Chemical)

頼戸井 宏行, 茅切 治, 武野 秀一, 橋本 真志

Synthesis of Some Polyhydroxylated Pyrrolidine Derivatives(Organic,Chemical)

頼戸井宏行

Exploratory Research Laboratories, Fujisativa Pharmaceutical Co., Ltd.
茅切治

Exploratory Research Laboratories, Fujisativa Pharmaceutical Co., Ltd.
武野秀一

Exploratory Research Laboratories, Fujisativa Pharmaceutical Co., Ltd.
橋本真志

Exploratory Research Laboratories, Fujisativa Pharmaceutical Co., Ltd.

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説明

Polyhydroxylated pyrrolidine derivatives, 7, 11, 15, and 18, were synthesized from 4, a. key intermediate for our total synthesis of swainsonine (1). The immunostimulating activities of these new derivatives were found to be moderate and less than that of swainsonine.