A new peptide synthesis using 2-fluoro-1,3,5-trinitrobenzene. Syntheses of thyrotropin releasing hormone and leucine-enkephalin

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2-Fluoro-1,3,5-trinitrobenzene has been found to be a useful new condensing reagent for peptide synthesis. A variety of dipeptides have been prepared from the corresponding amino acids with the reagent. The Young test under certain conditions did not cause racemization during the procedures. Subsequent application of this reagent enabled the syntheses of thyrotropin releasing hormone and leucine-enkephalin in good yields.

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