Morphological traits, cell proliferation and apoptosis in adrenocortical x-zone in pregnant mice
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説明
Adrenocortical X-zone, a transitory cortical region in virgin female and immature male, exists exclusively in mice, and its detailed nature, regression and turnover remain unclear. In this study, the X-zone was investigated in pregnant Jcl:ICR mice, in aspects of morphological traits, cell proliferation by bromodeoxyuridine (BrdU) immunohistochemistry and apoptosis by in situ nick endlabeling of genomic DNA (TUNEL). In the early pregnancy, the intact X-zone, which took more than 30 % of the total adrenocortex, was composed exclusively of non-vacuolated cells, with smaller size and a darker nuclei than other permanent cortical cells. From day 8 of gestation, the X-zone involuted gradually and this degeneration process lasted about one week. There are similarities and discrepancies between Jcl:ICR mice and reported other strains in cellular composition and period of the involution, suggesting strain-difference due to genetic background. BrdU immunohistochemistry demonstrated an apparently more active cell proliferation in the intact X-zone than in other permanent cortical zones. Apoptotic cells were not observed during the X-zone involution by either hematoxylin-eosin staining or TUNEL.
収録刊行物
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- Shimane journal of medical science
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Shimane journal of medical science 17 (1), 19-23, 1999-06-01
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詳細情報 詳細情報について
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- CRID
- 1570572702717015040
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- NII論文ID
- 120005582453
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- NII書誌ID
- AA00841586
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- ISSN
- 03865959
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- Web Site
- http://ir.lib.shimane-u.ac.jp/5901
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles