METABOLISM OF ANTHRAQUINONE:I. ISOLATION OF 2-HYDROXYANTHRAQUINONE FROM THE URINE OF RATS

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1. A study was made on the metablism of anthraquinone by oral dosing.<br> 2. Yellow crystals were isolated from ether extract of the urine either by recrystallisation with ethanol and water or sublimatisation at about 200°.<br> 3. The properties of the isolated substance was examined by its melting point, solubility in organic solvents and alkalis, and the absorbtion measurements, in 50 per cent ethanol, 0.1N sodium hydroxide solution, and concentrated sulfuric acid. These properties showed a good agreement with those of 2-hydroxyanthraquinone.<br> The authors wish to express their gratitude to Prof. Shibata of the Tokyo University for supplying them with hydroxy derivatives of anthraquinone and Dr. Yoshikawa for his help in these experiments.

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