Two Cases of Immediate-Type Hypersensitivity Caused by Oxaliplatin

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  • Shimizu Yuki
    Department of Dermatology, National Hospital Organization Osaka Minami Medical Center
  • Morimoto Shigefumi
    Department of Medicine, National Hospital Organization Osaka Minami Medical Center
  • Kosaka Hiroshi
    Department of Dermatology, National Hospital Organization Osaka Minami Medical Center

Bibliographic Information

Other Title
  • オキサリプラチンによる即時型アレルギーの２例

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Description

Oxaliplatin has become a pivotal drug as a part of FOLFOX4 chemotherapy against the colon cancer. Here we show two cases of colon-cancer-bearing females, both stricken by hypersensitive reaction just in a few-minute infusion of oxaliplatin. Case 1 : a 52 year-old female, having been attacked by dyspnea and itchiness in the hands at the seventh term of FOLFOX4, was proven clearly positive to oxaliplatin in intracutaneous test. Although a combination of dexamethasone, cetirizine and hydroxyzine were previously taken before the next term to prevent hypersensitivity, the crucial reaction was hardly circumvented. Case 2 : a 46-year old female, having been suffered from general urticaria at the ninth term, showed weakly but significantly positive in intracutaneous test. Rechallenge to her was canceled based on the experience of the previous case.

Journal

  • Skin research

    Skin research 6 (6), 582-586, 2007

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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