戦場における高脂血症管理に関する調査研究 : 食事療法とHMG-CoA還元酵素阻害剤(simvastatin)併用療法の有効性の検討 - 産推研・脂質介入試験 II (S-LIT II) -

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  • Multi-center prospective in Japanese male workers with hyperlipidemia : Changes in lipid profile with diet therapy and simvastatin treatment - The Sansuiken-Lipid Intervention Trial-II (S-LIT II) -

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The Sansuiken-Lipid Intervention Trial (S-LIT) was an intervention study to assess: 1) the acceptability and long-term compliance for a management program for hypercholesterolemia (serum total cholesterol concentration, TC<220mg/dl) in Japanese male workers, ≥40 years old; and 2) the relationship between serum cholesterol (TC) levels and the onset of ischemic heart disease (IHD). This interim report compared the long-term (3 years) serum lipid profile in the three cohorts; drug (simvastatin) treatment group (DT), diet-intervention group (DI), and non-treatment group (NT), which were draum from 1, 143 workers with hypercholesterolemia, patients were assigned to groups according to their own perference, not by randomization. The DT group had the highest initial levels of TC, triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) among the 3 groups. However, The DT group demonstrated the most improvement in normalizing TC (DT=34.2%, DI=7.9%, and NT=11.4%), high density lipoprotein cholesterol (HDL-c) (DT=47.6%, DI=46.3%, and NT=23.8%) and LDL-c (DT=50.0%, DI=19.3%, and NT=13.8%). While there were no differences in normalizing serum triglyceride (TG) levels. The dietary therapy (DI group) did not Show any improvement in lipid parameters in the cases with mild hyperlipidemia; with initial values of TC>250mg/dl, TG>250mg/dl, HDL-c<35mg/dl, and LDL-c>180mg/dl. These results suggest the importance of drug treatment using simvastatin for Japanese male worker with mild hyper-cholesterolemia, accordind to their lipid profiles.

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